An old HIV drug reversed paralysis and blindness in mice with MS
Researchers at the University of Virginia took an HIV drug, stripped out everything that made it work against HIV, and kept only the part that blocks the inflammasome, the cell-killing alarm system that runs amok in multiple sclerosis.
They gave the resulting drug, kamuvudine-9, to mice with MS-like disease, but not right away: they waited until the mice were already paralyzed and losing their sight, the way a real MS patient would be diagnosed 69. Over the next two weeks, those mice didn't just stop getting worse. They got their eyesight and their mobility back, something no mouse on a standard MS drug managed. A separate look at more than 3 million patient records found the same pattern in people: those already taking antiviral drugs related to K-9 had fewer MS relapses.