Bowel cancer stayed away for 33 months, and the eye has a hidden drain

Earlier results had 59% of patients showing no detectable disease after treatment and surgery. Now follow-up has reached 33 months, and none of the patients has had a recurrence. That includes the ones who still had small traces of cancer at surgery; in them, the leftover disease did not grow or spread 12. Under standard care, surgery followed by chemotherapy, about 25% of patients are expected to relapse within three years 12.

They named it the posterior ocular lymphatic outflow pathway, POLO for short, and they demonstrated it in mice 6. The retina is among the most metabolically active tissues in the body and constantly produces byproducts that have to go somewhere. "This discovery helps explain how the eye flushes this waste," says Dr. Neeru Gupta, head of UBC's department of ophthalmology and visual sciences 6.

After one year, those who learned the new foot position reported significantly less pain than those given a placebo treatment. The relief was comparable in size to benefits reported for some commonly used medications 1. MRI scans also showed slower deterioration in a marker of knee cartilage health. The team came from the University of Utah, New York University and Stanford, and the work was co-led by Scott Uhlrich 1.

In some, connections between regions were stronger than usual; in others they were weaker. One group with especially strong connections also had more pronounced substance abuse problems. Another, with weaker connections, showed more PTSD symptoms 8.

Ticking off that transition replaces the electrons that conventional atomic clocks use 3. The route there was short on paper and long in practice: Thorsten Schumm's group at TU Wien and Ekkehard Peik's team at PTB Braunschweig pinned down the transition experimentally in April 2024, and by that fall had hooked the thorium setup to a conventional optical atomic clock 3. Until now, prototypes needed a regular atomic clock to keep them in line. This one does not 3.

2 13. Winter is now installing remote cameras on what will be the world's largest wildlife overpass. He and his wife, the writer Sharon Guynup, also exposed conditions at the Tiger Temple in Bangkok, which closed afterward, and helped change US laws on big cats 13. Their retrospective, "Big Cats," came out from National Geographic Books this year 13.

After accounting for family circumstances, including the quality of the parent-child relationship, time on screens was not linked to emotional, behavioral or social difficulties at ages 5 or 10 27. At 15, teens who gamed five or more hours a day were more likely to have elevated difficulties than those who gamed under an hour. Teens who spent at least an hour a day on social media and messaging were less likely to 27. The paper appeared in JAMA Network Open.