The brain starts from two sets of cells, not one
Since 1952, the prevailing model has traced the whole brain to one shared pool of early cells, an idea from the Dutch scientist Pieter Nieuwkoop. A study in Nature Neuroscience, with Kyle Loh of Stanford among the authors, now describes two parallel sets of early cells.
One builds the forebrain and midbrain, the other builds the hindbrain, and each is restricted to its own territory from very early in development 140. Earlier cell-fate mapping had hinted at this but couldn't say whether cells were permanently committed or just following local chemical cues. "We certainly didn't expect to find that the brain comes from two different sources!" Loh said. He also pointed out that researchers in the 1990s had suspected multiple origins, and that his team built on their work 140.
