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Technology & Innovation Active Updated Jul 25, 2026

AI starts designing CRISPR gene editors from scratch

Researchers are using AlphaFold-style AI models to redesign CRISPR nucleases for higher precision and to design entirely new gene-editing proteins with no natural counterpart. The stakes are whether AI-generated editors can cut the off-target and bystander editing that has kept CRISPR from being safe enough for a wider range of diseases.

The story so far

  1. Jul 25, 2026 Latest

    Researchers used AlphaFold-style AI to redesign existing CRISPR nucleases for higher fidelity than earlier hand-tuned versions, and in a separate study used AI to design entirely new gene-editing proteins from scratch that successfully edited genes in cells from multiple species despite having no natural counterpart.

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