A cheap, decades-old pill finally helps with long COVID fatigue
In a trial of 399 adults in Brazil who'd had crushing, unrelenting fatigue for at least 90 days after COVID, researchers randomly gave people fluvoxamine, metformin, or a placebo for 60 days 1.
Fluvoxamine, an antidepressant that's been on the market since the 1990s and costs almost nothing, won out: the statistical analysis found a 99 percent probability it beat the placebo. "This is an important step forward for patients who have been desperate for evidence-based options," said Edward Mills of McMaster University, the trial's senior author 1. It's one of the first medications in the world to show a real, measurable benefit for a symptom that has sidelined millions of people from work and family life with nothing to show for years of searching.