The scientists who found sleep's missing switch, and the actor who fought for a cure
The Lasker Foundation, whose awards are sometimes called America's Nobel Prizes, gave its top basic-research honor this week to Dr. Emmanuel Mignot of Stanford and Masashi Yanagisawa of the University of Tsukuba, who independently tracked down the brain chemical that keeps us awake and is missing in people with narcolepsy 13.
Yanagisawa wasn't even looking for it. He was testing "orphan" receptors on brain cells, chemicals no one had matched to a trigger yet, when he and his team went fishing through rat brain tissue for the peptides that would switch them on. "We got very lucky, initially," he said. The fifth or sixth receptor they tried had a hit, and the trail led to two peptides made in the hypothalamus, the same region known for regulating hunger. A separate Lasker award for public service went to Michael J. Fox, honored for two decades of pushing Parkinson's research forward from the other side of the microscope, as a patient rather than a scientist 13. Each award carries a $250,000 honorarium, presented September 17 in New York.