A gene therapy that switches on with a pill cut seizures by more than 90%
Three people with drug-resistant epilepsy saw their monthly seizure counts fall by more than 90% after gene-carrying viruses were infused into their brains, in an early-stage trial reported in the New England Journal of Medicine 22.
The infusion went only to the small patch of tissue responsible for each person's seizures. The virus delivered a gene that made neurons there sensitive to clozapine, and the drug then activates the therapy and quiets the abnormal electrical firing 22. None of the three had a serious side effect 22.