A melanoma vaccine works, and a cavity gets painted shut

The vaccine, intismeran, comes from Moderna and Merck. Doctors sequence the tumor, work out what separates it from healthy cells, and send those targets to the immune system as mRNA, which Georgina Long of Melanoma Institute Australia calls a personalized "wanted poster" 16. The results were presented at the European Society for Medical Oncology meeting in Madrid and are set for the New England Journal of Medicine 16. Moderna CEO Stéphane Bancel said the company has worked on it for 10 years, and that most people in the field thought it would never work 23.

A dentist paints the 38 percent solution onto the cavity with a tiny sponge-tipped applicator. It takes seconds per tooth and needs no drilling, injection or sedation 1. Silver fights the bacteria and fluoride strengthens the tooth mineral. The trial appeared in JAMA Pediatrics 1.

These are called Lilliputian hallucinations, after the 6-inch residents of Gulliver's Travels 6. University of Utah researchers Colin Domnauer and Bryn Dentinger used DNA sequencing to identify Lanmaoa asiatica as the species behind the visions in southwest China and the northern Philippines, and reported it in Mycologia 6. The mystery goes back to Papua New Guinea in 1934. Even Albert Hofmann, who first isolated psilocybin, could not find a compound to explain it in samples sent to him 6. This time the team found no psilocybin and no other known psychoactive mushroom compound 6.

Two sit near the galaxy's center, separated by a projected 620 light-years, and are expected to merge eventually; the third lies about 5,500 light-years out. One weighs 80 million suns, and another is growing faster than conventional theories predict 7. Hannah Übler of the Max Planck Institute for Extraterrestrial Physics says it is the first evidence of three active black holes in one galaxy in the distant universe 7.

The vaccine is already moving: more than 74 million doses delivered since 2024, in routine immunisation in 25 African countries that carry more than 70 percent of the world's malaria. Four seasonal doses cut cases by about 75 percent where transmission is highly seasonal 137.

Levels were also higher after ultramarathons of up to 230 kilometers 35. Reduced anxiety after running showed up alongside the chemical changes. The study did not test whether one caused the other 35. Earlier work by the same group, led by senior author Johannes Fuss, found that runners who took a drug blocking opioid receptors still reported the usual calm and euphoria, which undercuts the old endorphin explanation 35.

Even the lowest-performing tape reduced leakage by 80 percent, against 70 percent for sandbags 122. The Bright Side notes the sandbag figure was for the best of 54 bags 133. Tape is cheaper, lighter, easy to store and does not rot, and unlike sandbags it can be thrown away without contamination worries 122. Door direction mattered too: an outward-opening door leaked 74 percent less than an inward-opening one before any protection was added 122.