Prime editing inside a patient, and free online help for new mothers

The target is Wilson disease, caused by mutations in a gene called ATP7B. That gene makes a protein that carries excess copper out of liver cells, and without it the copper builds up and can damage the liver and the nerves 25. The treatment rewrites DNA in the liver cells to erase the mutation. It does not switch the gene off. That distinction matters: Casgevy, the only gene-editing therapy the FDA has approved so far, uses CRISPR-Cas9, which is often used to disable genes rather than rewrite them 25. Base editing can fix single DNA letters but cannot make the corrections the most common ATP7B mutations need, so prime editing was the tool left standing 25.

The vaccine, intismeran autogene, is made for each patient. It targets neoantigens, the mutations unique to that person's tumor, and it rests on the same mRNA technology that produced the Covid-19 vaccines 90. Detailed numbers were presented at the European Society for Medical Oncology congress in Madrid, where oncologists called the result an important advance because patients lived significantly longer without their cancer returning 9097.

The program, Mindful Mood Balance for Moms, is free and self-paced. It adapts mindfulness-based cognitive therapy with peer videos and audio practices, and it came out of the University of Colorado Boulder and Massachusetts General Hospital 86. The trial was published in The Lancet Public Health 86. Participants also reported less everyday anxiety and less perceived stress 86.

Whole numbers such as 3, 7 and 12 and fractions such as 1/4, 2/3 and 5/8 landed on one shared map, with a topographic layout of numerical preference in the anterior inferior parietal cortex common to both 3585. The study was published October 22 in PLOS Biology 85.

The SunZia Wind and Transmission project powers over one million homes and generates more electricity than the Hoover Dam 136. It took about 20 years: permitting problems, lawsuits and, above all, an energy market that wasn't ready for the power it had to offer 136. When the turbines first came online, the head engineer called Pattern Energy's CEO to say "It works!", and at the ribbon-cutting some construction workers showed off new turbine tattoos 136.

Neurobiologists at the Max Planck Institute for Neurobiology of Behavior made the animals' brains transparent with a chemical procedure to build a 3D atlas, then exposed mole rats to magnetic fields that changed every 30 seconds, along with a near-zero field about 2% of Earth's strength in Germany 70. The strongest, most widespread brain response came from the near-zero field, with extra activity in regions linked to stress, anxiety and fear, including the amygdala 70. The researchers say this is the first time a mammal has been shown actively avoiding the absence of a magnetic field 70. In this experiment the loudest signal was a missing one.

Between March 2025 and May 2026, field teams made 12 expeditions and spent more than 130 days on the island's rugged terrain removing the animals, working with local landowners, Island Conservation and Samoa's environment ministry 229. A year on, project manager Paul Jacques reports native seedlings carpeting the forest floor, knee-high where regeneration had been suppressed, and giant taro growing where crops would have failed 229. One month after the removal, researchers found active nests with eggs in bird's-nest ferns, a spot that had been highly vulnerable to invasive species 229.