Cancers treated by their genes, and a mouse embryo's family tree

His mother, a cancer researcher, pushed him toward a newer kind of test that ignores where a cancer started and reads the gene driving it instead. Huff's tumour carried an alteration that a recently approved drug targets. Within weeks he felt better, and his first scan showed basically every tumour site had either shrunk or gone away 49. The same approach is now keeping more people alive through lung, pancreatic and brain cancers once considered death sentences 49.

They used a recorder called DNA Typewriter: a redesigned recording sequence, the "tape," was inserted into the genome of a fertilized mouse egg, and as the cells divided it logged their divisions so their ancestry could be reconstructed afterward 18. The record covers the first 13.5 days of development, out of a 19-to-21-day mouse gestation, and appeared October 8 in Science 18. One early result: different cell types emerge on their own schedules rather than in lockstep 18.

A doctor threads a thin catheter to specific blood vessels in the knee and releases microscopic particles that dissolve within hours, interrupting the abnormal vessel growth and inflammation that feed chronic pain 2. Of the patients assessed at the one-year follow-up, 80% reported clinically meaningful pain relief lasting at least 12 months, according to results in the journal Radiology 2.

On day 226, Gavi reported a preliminary dashboard showing maternal deaths down 32.2 percent against a 2025 baseline, child deaths down 12.3 percent, and 10,113 zero-dose children reached 279. Behind those figures is nurse Increase Conteh, who once a week walks the alleys of Congo Town, a settlement of about 24,000 people on reclaimed land, with a vaccine carrier and a notebook of children who missed their jabs 279.

Earlier reviews had reported small increases in risk, but the associations shrank when the team focused on the highest-quality evidence; small associations remained in some analyses 141. The team quantified the overlap between reviews, appraised their quality and reanalyzed the underlying studies by risk of bias, after finding that "many counted the same primary studies several times without acknowledging it" 141.

It also sits directly in front of galaxies even farther away, and its gravity bends their light into strong gravitational lensing, which makes it the most distant cluster known to do that 5. Three papers from IPAC at Caltech examine the cluster, and Kyle Finner, lead author of the first, recalls the team's reaction to the first images: "wow, look at this, there's strong lensing coming from this cluster!" 5

Pale purple, grapefruit-sized pearl octopuses (Muusoctopus robustus) crowd roughly 6.2 acres of seafloor over a field of hydrothermal springs, the largest known deep-sea octopus congregation on Earth 281. Researchers counted about 6,000 using underwater mapping and extrapolated the rest 281.