Psilocybin Temporarily Restored Speech and Mobility in Advanced Alzheimer's
A psychiatrist in São Paulo named Marcos Lago was treating an 80-year-old woman with advanced Alzheimer's disease, a stage where significant functional recovery is considered essentially impossible, when he made a decision to try psilocybin.
What followed surprised him. After a high-dose session, the patient temporarily regained specific communication abilities and daily-living functions that had been lost to the disease. The case report, published in Frontiers in Neuroscience, documents what the team describes as dormant capacities reawakening in late-stage neurodegeneration [94]. The proposed mechanism: psilocybin's active metabolite, psilocin, binds to serotonin 5-HT2A receptors and appears to briefly stimulate neuroplasticity, temporarily reshuffling large-scale brain networks including the default mode network, which is heavily disrupted in Alzheimer's [94].
What each field noticed (3)
An 80-year-old woman with advanced Alzheimer's regained speech and mobility after taking psilocybin
This is a single case report, not a trial, so the finding is the beginning of a question rather than an answer. What it shows is that some brain networks retain latent capacity even in late-stage neurodegeneration. The fact that psilocin can briefly reach and temporarily activate those circuits is what makes this worth studying in controlled trials [94].
Read the storyAn 80-year-old woman with advanced Alzheimer's regained speech and mobility after taking psilocybin
Psychology has been watching the psychedelic renaissance with close attention. The Alzheimer's case raises a specific and hopeful question: if the disease blocks access to preserved capacity rather than erasing that capacity entirely, then interventions aimed at neuroplasticity might offer a symptom-management window that current approaches completely miss [94].
Read the storyMushrooms and Our Search for Meaning
Maria Popova's essay on fungi runs in the background here like a long note: mushrooms have been a part of human experience and medicine for millennia, yet the kingdom fungi was not even formally distinguished from plants until the 20th century. The humble mushroom that may wake up a silenced Alzheimer's patient is the same organism humans have been foraging, revering, and telling stories about for as long as we have told stories [242].
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